Our study detected a robust genetic association with GLP1 medication weight loss efficacy and associated side effects
Zheng et al showed that GLP-1 RA use was associated with a lower risk of DR in 2,390 patients in a national Swedish registry using both observational and genetic data
J Clin Endocrinol Metab 37(5):826828 Elahi D, Andersen DK, Brown JC et al (1979) Pancreatic alpha-and beta-cell responses to GIP infusion in normal man
You can read more about G proteins in a previous Molecule of the Month article
These cerebral actions of GLP-1 are unlikely to reflect the actions of peripherally produced GLP-1 but are rather targets for GLP-1 produced in and released from projections of neurons of the nucleus of the solitary tract, which express the proglucagon gene and have a processing pattern like the L cells of the gut
GLP-1 medications like Ozempic, Mounjaro, and Wegovy are commonly prescribed to help manage type 2 diabetes and support weight loss